* Some TAA targets are expressed in healthy tissues or cells and perform important physiological functions, and drugs directing against such targets may have serious toxic side effects. Therefore, Biocytogen provides corresponding humanized animal models for drug safety evaluation.
B-hHLA-E MC38 plus
B-hPD-L1 plus/hCD47 MC38
B-hPD-L1 plus/hCEA MC38
Drug target-humanized mice are animal models thatmurine protein drug target is knock out, and the human counterpart protein knocked in. This model overcomes species specificity issues of syngeneic models, which can only be used for surrogate antibodies. Also, it provides more stable results than the model of human immune system reconstitution in immunodeficient mice. This model can be used to evaluate immunotherapy efficacy because of its health immune system .
Biocytogen has created a number of humanized mouse models with single, dual, or multiple targets in response to the current market need for innovative drug development. The company has also developed humanized tumor cell lines according to the potential drug action mechanisms, so as to provide a more comprehensive and effective disease model for drug efficacy evaluation.